Cytoplasmic WEE1 Mediates Immunotherapy Resistance via AKT Signaling in NANOG⁺ Tumors (IMAGE)

Korea University College of Medicine

Cytoplasmic WEE1 Mediates Immunotherapy Resistance via AKT Signaling in NANOG⁺ Tumors

Caption

WEE1 promotes immune resistance in NANOG-high tumors by activating the HSP90A/TCL1/AKT pathway, reducing the effectiveness of PD-1 blockade, and highlighting a promising target for cancer immunotherapy.

Credit

Professor Tae Woo Kim, Korea University College of Medicine, Republic of Korea

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