Synergistic metabolic reprogramming via stearic acid-functionalized hexavanadate nanovesicles loaded with palmitic acid hydroxystearic acids (IMAGE)

Tsinghua University Press

Synergistic metabolic reprogramming via stearic acid-functionalized hexavanadate nanovesicles loaded with palmitic acid hydroxystearic acids

Caption

Self-assembled SA-V6/PAHSA nanovesicles traverse the intestinal barrier to target metabolic tissues. Structural visualization showing stearic acid tails and PAHSAs stabilizing hexavanadate clusters. Dual therapeutic actions, PTP1B inhibition enhances insulin receptor phosphorylation and GPR120 activation in adipose tissue suppresses proinflammatory factor secretion. Restored metabolic homeostasis in HFD mice evidenced by normalized glucose curves and lipid profiles.

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Polyoxometalates, Tsinghua University Press

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