Plasma Metabolomic Profiling of Active TB Patients Versus Healthy Controls (IMAGE)
Caption
lasma metabolomic analysis in active tuberculosis patients and healthy controls.
(A) PCA score plot of active TB patients (n = 36) and HCs (n = 44) based on metabolomic data. (B) OPLS-DA score plot of TB patients (n = 36) and HCs (n = 44) based on metabolomic assay. (C) Permutation and prediction tests were performed to validate the OPLS-DA classification model by using metabolomic data. (D) Heatmap of 15 amino acid contents in the plasma from active TB patients and HC derived from 1H NMR assay. (E) Relative concentrations of four amino acids (mean ± SEM) in TB and HCs. (F) OPLS-DA score plot of active TB patients (n = 36) and HCs (n = 44) by using 4-aminobenzoate, phenylalanine, serine and threonine. (G) Permutation and prediction test to validate the OPLS-DA classification model by using 4 amino acids. Data were presented as mean ± SEM. ∗∗∗, P < 0.001
Credit
Yong Li, Cheng-cheng Yao, Ping Ji, Hui-yu Wang, Shu-jun Wang, Ying Wang, Qi-jian Cheng, Lu Xia, Ying-ying Chen.
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