Schematic representation of Gemini surfactants for gene delivery (IMAGE)

Sichuan International Medical Exchange and Promotion Association

Schematic representation of Gemini surfactants for gene delivery

Caption

Gemini surfactants improve transfection efficiency or biocompatibility through structural optimization, such as replacing the head group with imidazole or pyridine, using shorter spacers, incorporating longer hydrophobic tail chains, and modifying with small molecules, peptides, amino acids, and biomimetic strategies. Additionally, studies on the delivery mechanisms of Gemini surfactants, together with their future development strategies, have established a critical foundation for the advancement of gene therapy in disease treatment. AI, artificial intelligence; ER, endoplasmic reticulum; GS, Gemini surfactant; HCM, hepatocyte membrane; NA, nucleic acid; RBCM, red blood cell membrane.

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Huali Chen

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