Schematic illustration of HAase nanogel-armed CAR-T cell strategy (IMAGE)

Tsinghua University Press

Schematic illustration of HAase nanogel-armed CAR-T cell strategy

Caption

Upon systemic administration, H-NGs utilize the tumor trafficking of CAR-T cells to penetrate tumor tissues, bypassing the tumor vasculature system (Step 1). As the result, H-NGs on the cellular surface are stimulated by high concentrations of ROS in the TME (Step 2). Then, the HAase released from H-NGs effectively degrades the condensed tumor extracellular matrix (step 3). The degradation of the tumor matrix in solid tumors results in an increased infiltration of CAR-T cells (step 4) and a heightened antitumor response (step 5).

Credit

Nano Research, Tsinghua University Press

Usage Restrictions

News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.