The profibrotic role of EGR1high Epithelial cells in IgG4-Related Disease (IMAGE)

Science China Press

The profibrotic role of EGR1high Epithelial cells in IgG4-Related Disease

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EGR1high is present in IgG4-RD patients and contributes substantially to tissue fibrosis via EMT and direct activation of fibroblasts. Immune-epithelial interaction is an important driver of overexpression of EGR1 in epithelial cells.

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