Statins exhibit anti-tumor potential by modulating Wnt/β-catenin signaling in colorectal cancer (IMAGE)
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Figure 7: Statin mediated reduction in tumor burden via downregulation of SATB1 in vivo. (A) Schematic presentation of the experimental strategy using NOD-SCID mice. (B) Comparative images of the tumors and graph to show a reduction in tumor burden on simvastatin treatment in mice injected with HCT116 cell line, (Biological replicates n = 4) (C) FLAG-SATB1 overexpressed SW480 cells were injected sub-cutaneously in NOD-SCID mice, and tumor burden was observed after rosuvastatin treatment (n = 7) **p < 0.005, ***p < 0.0005 by performing Student’s t-test analysis.
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