Two monoclonal antibodies with the same target exhibit markedly different antitumor effects (IMAGE)

Chiba University

Two monoclonal antibodies with the same target exhibit markedly different antitumor effects

Caption

10F.9G2, a monoclonal antibody with high antibody-dependent cellular cytotoxicity, has an off-target effect that involves the reduction of CD8+ T cells. This surpasses the on-target effect, namely programmed cell death protein 1/programmed death-ligand 1 axis inhibition, resulting in no observable antitumor efficacy. In contrast, MIH6, which has low antibody-dependent cellular cytotoxicity activity, exerts only the on-target effect, leading to an effective antitumor response.

Credit

Assistant Professor Yuta Tamemoto from Chiba University, Japan Source link: https://www.sciencedirect.com/science/article/pii/S0378517325005927?via%3Dihub

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