Understanding the mechanism behind brain aging (IMAGE)
Caption
A decline in the expression of the epigenetic regulator Setd8 in neural stem cells (NSCs) during early adulthood leads to chromatin condensation and reduced gene expression, suppressing NSC proliferation and contributing to premature brain aging. This illustration depicts the transition of NSCs from an active to aged state, revealing the key mechanism underlying the onset of cognitive decline.
Credit
Dr. Taito Matsuda from Nara Institute of Science and Technology, Japan
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Original content