Whole-body [11C] carfentanil PET imaging at baseline and then following naloxone (IMAGE)

Society of Nuclear Medicine and Molecular Imaging

Whole-body [11C] carfentanil PET imaging at baseline and then following naloxone

Caption

Visual Abstract. Whole-body [11C] carfentanil PET imaging at baseline (left side of panel) and then following naloxone (middle panel) shows μ-opioid receptor (MOR) in the brain (color) and throughout the body.  Weight based naloxone administration results in greater MOR occupancy in women than men (top right blue/red figure showing differences in the thalamus, a brain structure rich in MOR expression).  Whole-body imaging imaging permits dynamic measurements in multiple regions, e.g. aorta, skeletal muscle, that could serve as reference regions. Figure by Chia-Ju Hsieh.

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Image created by Chia-Ju Hsieh, University of Pennsylvania, Philadelphia, Pennsylvania.

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