Schematic depiction of the lipid nanoparticle preparation (IMAGE)

Nagoya University

Schematic depiction of the lipid nanoparticle preparation

Caption

The modified lipid nanoparticle (CDL-LNP) contains several ingredients that work together to deliver mRNA effectively: the mRNA payload with genetic instructions, standard lipid molecules (ionizable lipids, phospholipids, cholesterol, PEG-lipids) that form the particle structure, and the new cyclic disulfide lipids (CDL) that help the mRNA escape from cellular traps once inside the cell.

Credit

Kimura et al., 2025

Usage Restrictions

Credit must be given to the creator.

License

CC BY

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