Development of a novel transcriptomic measure of aging: Transcriptomic Mortality-risk Age (TraMA) (IMAGE)
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Figure 1. (A) Plan of analysis for the current study. (B) Nested regression results from the HRS testing data including associations between TraMA and sociodemographic factors and health behaviors; points represent regression coefficients and bars represent 95% confidence intervals; all models include cell type and batch as covariates. Model 1 includes demographic factors; Model 2 includes variables in Model 1, as well as socioeconomic factors; Model 3 includes variables in Model 2, as well as health behaviors. (C) Regression results from the HRS testing data of health/aging outcomes on TraMA; points represent regression coefficients and bars represent 95% confidence intervals; all models include age, race/ethnicity, sex/gender, cell type, and batch as covariates. (D). Validation results from nested regression of time to death on TraMA in HRS and LLFS. Model 1 includes batch as a covariate; Model 2 includes batch, age, race/ethnicity, and sex/gender as covariates; Model 3 includes variables from Model 2, as well as RNA-based cell type as covariates.
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Copyright: © 2025 Klopack et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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