Molecular landscape of oral squamous cell carcinoma: novel biomarkers and therapeutic targets. (IMAGE)

Chongqing Medical University

Molecular landscape of oral squamous cell carcinoma: novel biomarkers and therapeutic targets.

Caption

Molecular landscape of oral squamous cell carcinoma: novel biomarkers and therapeutic targets. (A) Mendelian randomization analysis identified 73 pairs of causal risk. (B) Scatter plots of Mendelian randomization (MR) analysis of important genes in the validation set. (C) Forest plot of the leave-one-out test for single nucleotide polymorphisms (SNPs) associated with important genes in the validation set. (D) Associations between SNPs in key genes and diseases. (E) Cell annotation of 21 clusters. (F) Differences in the proportion of 8 cell types between the two sample groups. (G) Expression of key genes in single cells. (H) Correlation of key genes with immunometabolism. (I) Gene co-expression of mitochondria-related genes with key genes in single-cell data and the co-expressed gene correlations. (J) Gene set enrichment analysis (GSEA) of critical genes. (K–M) Correlation between nomogram model construction and tumor progression genes. (N) Drug sensitivity correlation of key genes. (O) Graphical abstract.

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Genes & Diseases

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