The schematic diagram illustrates the synergistic anti-tumor effect of the combination of mitochondrial transplantation and cisplatin. (IMAGE)

China Anti-Cancer Association

The schematic diagram illustrates the synergistic anti-tumor effect of the combination of mitochondrial transplantation and cisplatin.

Caption

The schematic diagram illustrates the synergistic anti-tumor effect of the combination of mitochondrial transplantation and cisplatin. Mitochondrial transplantation combined with cisplatin inhibited tumor stemness by diminishing HIF-1α and reducing lactate accumulation. Mitochondrial transplantation plus cisplatin triggered the ROS-mediated mitochondrial apoptotic pathway. The combination of mitochondrial transplantation and cisplatin boosted T and NK cell-mediated anti-tumor immunity by preventing the Wnt/β-catenin pathway to inhibit tumor development.

Credit

Cancer Biology & Medicine

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CC BY-NC

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