New Insights into Rheumatoid Arthritis Inflammation (IMAGE)

Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University

New Insights into Rheumatoid Arthritis Inflammation

Caption

The IGFL2 gene encodes a cytokine found in primates, which are closely related to humans. In the joint tissue of people with rheumatoid arthritis, peripheral helper T (Tph) cells express IGFL2, which increases the expression of CXCL13, a protein that promotes autoantibody production. Additionally, IGFL2 activates immune cells called monocytes and macrophages, further amplifying inflammation and worsening joint damage.

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WPI-ASHBi/Kyoto University

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