Parkinson’s disease-linked DJ-1 prevents cellular damage by hydrolyzing a highly reactive glycolysis side product (IMAGE)

Institute of Science Tokyo

Parkinson’s disease-linked DJ-1 prevents cellular damage by hydrolyzing a highly reactive glycolysis side product

Caption

Mutation of DJ-1 is implicated in hereditary Parkinson’s disease. However, the exact molecular mechanism of its pathophysiological role was unknown. Researchers from Japan used molecular simulations and biochemical mutational assays to reveal the key residues involved in its catalytic function of converting cyclic 3-phosphoglyceric anhydride—a highly reactive glycolysis side product—to 3-phosphoglycerate, protecting cells from damage.

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Institute of Science Tokyo

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