Lifestyle interventions reshape gene regulation in skeletal muscle of Asians (IMAGE)

National University of Singapore

Lifestyle interventions reshape gene regulation in skeletal muscle of Asians

Caption

Graphical summary of the study. Overweight or obese East Asian individuals underwent a 16-week lifestyle intervention involving diet and exercise. The study revealed improvements in metabolic health, changes in skeletal muscle gene expression, and genetic regulation patterns influenced by lifestyle. Hundreds of response-specific gene regulatory variants (e/sQTLs) were identified, including many unique to Asian population. Integration with metabolic GWAS data highlighted 16 candidate genes associated with disease risk.

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National University of Singapore

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