Mini-Cog score showing a nearly linear negative correlation with POD risk (IMAGE)

Sichuan International Medical Exchange and Promotion Association

Mini-Cog score showing a nearly linear negative correlation with POD risk

Caption

Analyzing the Mini-Cog score as a continuous variable, it was found to have a nearly linear negative correlation with POD risk: for each 1-point increase in the score, the risk of POD decreased by 23% (unadjusted OR = 0.77, p < 0.001). Even after multi-factor adjustment (adjusting for demographic factors, preoperative comorbidities, and intraoperative factors such as intraoperative hypotension and blood transfusion), each 1-point increase still reduced the risk by 16% (OR = 0.84, p = 0.003). Furthermore, the study innovatively combined Mendelian randomization analysis, mainly based on 139 cognitive function-related SNPs in the European population. These SNPs are functionally enriched in pathways such as synaptic plasticity and neural development, suggesting that cognitive impairment and delirium may share common neural mechanisms.

Credit

Ailin Luo

Usage Restrictions

Marked by the credit.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.