Periodontal tissue regeneration via MSC-EC signaling leading to angiogenesis-osteogenesis coupling. (IMAGE)

Editorial Office of West China School of Stomatology, Sichuan University

Periodontal tissue regeneration via MSC-EC signaling leading to angiogenesis-osteogenesis coupling.

Caption

In a recent study, researchers from China used single-cell transcriptomics, bioinformatic, and biological assays to reveal a unique interlineage crosstalk in dental regeneration. PDGFRA positive MSCs interact with ECs via VEGFA and PDGFBB, which helps maintain the functionality of the MSCs and drives angiogenesis in the system. This paracrine signaling facilitates periodontal bone regeneration in vivo and may have potential applications in regenerative medicine.

Credit

Dr. Fang Jin from The Fourth Military Medical University, Xi’an, China Image Source Link: https://www.nature.com/articles/s41368-025-00384-6

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License

CC BY

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