Pathogenic mechanisms of nephrotic syndrome caused by anti-nephrin antibody. (IMAGE)

Niigata University

Pathogenic mechanisms of nephrotic syndrome caused by anti-nephrin antibody.

Caption

(Upper panel) Normal podocytes: Ephrin-B1 at slit diaphragm interacts with nephrin via the extracellular site and with Par6 via the cytoplasmic site. (Lower panel) Podocytes stimulated by anti-nephrin antibody: The stimulation by the antibody induces the phosphorylations of nephrin and ephrin-B1 in a Ca2+ influx–dependent manner. Phosphorylated-ephrin-B1 is dissociated from nephrin and also from Par6, and Par6 comes to interact with cdc42, and the binding of Par6 promotes cdc42 activity. Elevated cdc42 activity promotes calcineurin (CaN) activity, activates Snail, a transcription factor, and decreases mRNA expression of nephrin and ephrin-B1.

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Niigata University

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