TOC: Construction of Region-Specific Liver Organoid and Fabrication of Hierarchical Functional Liver Lobule for Liver Disease Modeling and Drug Evaluation (IMAGE)

Science China Press

TOC: Construction of Region-Specific Liver Organoid and Fabrication of Hierarchical Functional Liver Lobule for Liver Disease Modeling and Drug Evaluation

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The central vein (CV) region, driven by the Wnt signaling pathway, and the portal vein (PV) region, driven by the Notch signaling pathway, enable us to construct a biomimetic liver lobule microenvironment model with distinct functional and structural zones using genetic engineering and tissue engineering techniques.

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