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Higher Education Press

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This review illustrates how the nuclear phosphoinositide-p53 signalosome integrates lipid signaling and p53 function to regulate cancer cell motility. The figure contrasts the tumor-suppressive actions of wild-type p53 with the oncogenic properties of mutant p53, highlighting how distinct PIPn-driven signalosomes influence nuclear AKT activation, cytoskeletal dynamics, and metastasis-related behavior.

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Xiaoting Hou, Yu Chen, Bo Zhou, Fengting Liu, Lingyun Dai, Chunbo Chen, Noah D. Carrillo, Vincent L. Cryns, Richard A. Anderson, Jichao Sun, Mo Chen

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