Non-native entanglement (IMAGE)
Caption
Recently identified and long-lasting type of protein misfolding — non-native entanglements — observed in all-atom protein folding simulations. Representative misfolded conformations of the small proteins, Ubiquitin and λ-repressor, exhibit gains-of-entanglement in all-atom folding simulations and are shown alongside their native structures. In the misfolded states, non-native entangled loops are highlighted in red, with yellow spheres marking loop closures and blue segments indicating threading through the loop.
Credit
O’Brien Laboratory, Penn State
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License
CC BY-NC-ND