Combating Bacterial Resistance with Peptide Combinations (IMAGE)
Caption
The figure illustrates a key strategy to prevent the evolution of antimicrobial resistance. When bacteria are treated with a single antimicrobial peptide (AMP)—from a source like a honeybee (top) or a frog (bottom)—they can rapidly evolve resistance, which renders the treatment ineffective. However, when the bacteria are treated with a combination of different AMPs, they are effectively killed (center), and their ability to evolve resistance is significantly hindered. This approach makes peptide combinations a promising strategy for developing more durable, 'resistance-proof' therapies.
Credit
Bar Maron, The Hebrew University of Jerusalem, the figure created with Biorender.com
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