Vascular aging is a critical process that plays a central role in the development of various age-related diseases. (IMAGE)

Tsinghua University Press

Vascular aging is a critical process that plays a central role in the development of various age-related diseases.

Caption

Vascular aging is a complex pathophysiological process propelled by endothelial dysfunction, oxidative stress, chronic inflammation, cellular senescence, endothelial stiffening, and vascular smooth muscle cell (VSMC) alterations. These interconnected mechanisms drive a self-reinforcing cycle that progressively compromises vascular integrity, exacerbates endothelial dysfunction, and accelerates aging. Ultimately, this cycle promotes vascular stiffness and maladaptive remodeling—hallmarks of aged vessels—and significantly increases susceptibility to cardiovascular diseases.

Credit

Aging Research, Tsinghua University Press

Usage Restrictions

News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.