lipid metabolism plays a crucial role in Alzheimer’s disease (AD) pathogenesis, positioning it as a potential target for therapeutic intervention. (IMAGE)

Tsinghua University Press

lipid metabolism plays a crucial role in Alzheimer’s disease (AD) pathogenesis, positioning it as a potential target for therapeutic intervention.

Caption

AD is associated with significant changes in genes related to neuroinflammation, and lipids are crucial in this metabolic dysregulation. Abnormal phospholipid accumulation in the brain not only activates microglia but also stimulates the secretion of pro-inflammatory cytokines, such as IL-6, highlighting the strong connection between lipid metabolism and neuroinflammation in AD.

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Aging Research, Tsinghua University Press

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