Adrenomedullin as an Immunomodulator of CD14+MerTK+ Circulating Monocytes in Liver Failure Syndromes (IMAGE)

Xia & He Publishing Inc.

Adrenomedullin as an Immunomodulator of CD14+MerTK+ Circulating Monocytes in Liver Failure Syndromes

Caption

Adrenomedullin is increased in acute liver failure syndromes (ALF and ACLF), and AMBP1 is, on the contrary, reduced, mirroring the severity of the disease expressed by the SOFA score. ADM affects monocyte function, increasing MerTK after LPS stimulation and promoting a pro-restorative, anti-inflammatory phenotype. Further studies are needed to fully understand how to modulate this pathway as a possible therapeutic target and restore monocyte function.

Credit

Francesca Maria Trovato

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License

CC BY-NC

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