Fig. 1 (IMAGE)

The University of Osaka

Fig. 1

Caption

Polβ-dependent DNA demethylation is essential for neuronal development.

During neuronal development, DNA demethylation at enhancer regions is required to activate gene expression. In the absence of DNA polymerase β (Polβ), indel mutations near CpG sites increase approximately ninefold, highlighting the critical role of Polβ in maintaining genome integrity during epigenetic reprogramming.

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Noriyuki Sugo

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