Discovery of brown adipocytes-β-cell crosstalk during type 1 diabetes progression via ZNF638-RBP4-retinol-ATRA axis (IMAGE)

Science China Press

Discovery of brown adipocytes-β-cell crosstalk during type 1 diabetes progression via ZNF638-RBP4-retinol-ATRA axis

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ZNF638 in brown adipose tissue (BAT) exacerbates type 1 diabetes (T1D) by suppressing retinol-binding protein 4 (RBP4), thereby disrupting all-trans retinoic acid (ATRA)-mediated protection of pancreatic β-cells

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