Pharmacotherapeutic strategies targeting the fundamental pathobiology of ATTR. (IMAGE)

First Hospital of Jilin University

Pharmacotherapeutic strategies targeting the fundamental pathobiology of ATTR.

Caption

It elucidates the series of events involving the dissociation, misfolding and aggregation of TTR proteins, resulting in the formation of amyloid fibrils. It also higlights various therapeutic approaches and existing pharmacological treatments for the management of ATTRv. ASO, antisense oligonucleotide; ATTR, transthyretin amyloidosis; ATTRv, hereditary ATTR; CRISPR, clustered regularly interspaced short palindromic repeats; RNAi, RNA interference; TTR, transthyretin.

Credit

By Intissar Anan

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted.

License

CC BY-NC

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