22Q, mitochondria and the blood brain barrier (IMAGE)
Caption
A genetic condition known as 22q.11.2 deletion syndrome is associated with an increased risk of mental illness. A Penn Vet and CHOP collaborative team found that mitochondrial function is required for proper BBB function. Importantly, an intervention aiming to improve mitochondria function reverts BBB deficits and improves behavioral outcomes in a preclinical model of 22qDS. An image taken through scanning electron microscopy shows healthy mitochondria in brain endothelial cells from 22qDS animals treated with bezafibrate (Image: courtesy of the Alvarez lab).
Credit
the Alverez lab of the University of Pennsylvania School of Veterinary Medicine
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