figure_2 (IMAGE)
Caption
Schematic of horizontal elongation in an optimized cell cluster. (a) Left: The final configuration of a simulation with randomly initialized parameters; right: The final simulation state after learning. Source cells, in red, secrete the growth factor and cannot divide. Proliferating cells, in gray, sense the growth factor and divide in response to it. (b) The learned gene network. The receptor gene is activated only by the presence of the external chemical factor, which results in repression of the division propensity. (c) Chemical gradient created by source cells along the cluster x-coordinate. (d) Division propensity distribution at the end of the simulation along the x-axis, highlighting the concentration of dividing cells at the tip.
Credit
Brenner group / Harvard SEAS
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Original content