Weaving peptide nanonets to fight bacterial infections (IMAGE)
Caption
Rational design of peptide side strands with key amino acid residues modulates peptide nanonet morphology. Fine-tuning the aromaticity of the peptide resulted in W-W13, which forms tightly interwoven nanonets on bacterial surfaces. In contrast, reducing the positive charge in E-E13ASYM led to extensive, loosely self-interwoven nanonets that trap bacteria less effectively. Scanning electron microscopy images show the distinct tight and loose nanonets trapping Escherichia coli. Magnification: ×15,000; scale bar = 1 µm.
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National University of Singapore
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