Altered periodontal tissue remodeling in orthodontic tooth movement under hypoxia (IMAGE)

Institute of Science Tokyo

Altered periodontal tissue remodeling in orthodontic tooth movement under hypoxia

Caption

By utilizing a closed-coil spring made of nickel-titanium to cause orthodontic tooth movement (OTM) in rats and housing them inside a controlled-atmosphere chamber with 10% oxygen, scientists from Institute of Science Tokyo, Japan, have investigated the molecular and cellular mechanisms involved in OTM under hypoxia. Oxygen deprivation resulted in increased osteoclast activity on the compression side and limited formation of new bone tissue on the tension side after OTM.

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Institute of Science Tokyo

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