Variable morphologic features of high-grade serous carcinoma involving the cervix (IMAGE)

Xia & He Publishing Inc.

Variable morphologic features of high-grade serous carcinoma involving the cervix

Caption

(a) Papillary growth pattern with columnar, pseudostratified tumor cells. This morphology can mimic HPV-associated usual-type endocervical adenocarcinoma. (b) Solid growth composed of round to ovoid tumor cells, with frequent mitotic figures including atypical mitoses. (c) Papillary architecture with hobnailing high-grade tumor cells and clear cytoplasm, which requires distinction from clear cell carcinoma. (d) Infiltrating glandular tumor cells with hyperchromatic, “smudgy” nuclei. Conspicuous mitoses, including atypical forms, and apoptosis are present. (e) Discohesive tumor cells with marked nuclear pleomorphism. (f) Loosely cohesive tumor cells associated with psammoma bodies. Magnification: a-f: 400×.

Credit

Tong Sun

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License

CC BY-NC

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