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Synonymous gene recoding through codon (CO) and codon-pair (CPO) optimization strategies affects ADAMTS13 expression, structure, stability, cellular bioenergetics, PMTs and immunogenicity. Thus, careful evaluation of the recoded transgene is needed as it can uncovered undesirable protein properties
Credit
Brian C. Lin, Katarzyna I. Jankowska, Upendra K. Katneni, Randilu Amarasinghe, Nigam Padhiar, Nobuko Hamasaki-Katagiri, Wells W. Wu, Zhu Haojie, Hideki Taguchi, Arnab Ghosh, David D. Holcomb, Je-Nie Phue, Sarah E. Fumagalli, Darón I. Freedberg, Ofer Kimchi, Rong-Fong Shen, Anton A. Komar, Zuben E. Sauna, Chava Kimchi-Sarfaty
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