Triggering RNA activation on demand (IMAGE)

National University of Singapore

Triggering RNA activation on demand

Caption

This work presents a redox-responsive strategy for precise RNA control via post-synthetic 2′-OH acylation. These introduced disulfide-containing acyl groups can be selectively cleaved upon exposure to both exogenous and endogenous glutathione (GSH), enabling traceless RNA release and functional recovery. This approach offers a versatile tool for modifying and manipulating RNAs of diverse lengths or origins.

Credit

Angewandte Chemie International Edition

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