Plasma microbial signatures of patients with liver tumours. (IMAGE)

First Hospital of Jilin University

Plasma microbial signatures of patients with liver tumours.

Caption

(a) Schematic representation of study design, experimental and computational processing including host filtration using the Human Pangenome Reference Consortium, microbial classification using Qiita and laboratory-associated decontamination with SCRub. (b) Differences in community structure represented by the RPCA-PCoA between the plasma of participants with primary liver tumour (HCC) or with metastatic liver tumour (mCRC) (RPCA-PERMANOVA, p=0.015). (c) Top and bottom 10 microbial taxa associated with primary liver tumour (HCC, green) or metastatic liver tumour (mCRC, pink).The left panel represents the differential abundance rankings from BIRDMAn. The right panel represents the relative abundances for each participant and average for each condition. BIRDMAn, Bayesian Inferential Regression for Differential Microbiome Analysis; cfDNA, cell-free DNA; HCC, hepatocellular carcinoma; mCRC, metastatic colorectal cancer; PCoA, Principal Coordinates Analysis; PERMANOVA, Permutational Multivariate Analysis of Variance; RPCA, Robust Principal Coordinates Analysis.

Credit

By Caitlin Guccione, Ana Carolina Dantas Machado, Fady Youssef, et al.

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted.

License

CC BY-NC

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