Schematic diagram of DDX17-induced hepatocellular carcinoma metastasis mechanism (IMAGE)

Sichuan International Medical Exchange and Promotion Association

Schematic diagram of DDX17-induced hepatocellular carcinoma metastasis mechanism

Caption

The diagram illustrates the key mechanisms of DDX17-induced hepatocellular carcinoma metastasis: DDX17 promotes nuclear translocation of β-catenin; in the nucleus, β-catenin forms a complex with TCF4, which directly binds to the DDX17 promoter to enhance its transcription, forming a positive feedback loop. This loop drives epithelial-mesenchymal transition (EMT) and ultimately facilitates the migration, invasion, and metastatic spread of HCC cells.

Credit

Junjiang Fu and Chaoxiang Lv

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