Loss of Trp53 results in a hypoactive T cell phenotype accompanied by reduced pro-inflammatory signaling in a syngeneic orthotopic mouse model of ovarian high-grade serous carcinoma (IMAGE)
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Figure 1: OVE4-Trp53ko cells produce advanced disease in a syngeneic, orthotopic mouse model of HGSC. (A) Schematic for orthotopic injection of OVE4 cell lines into FVB/n mice. (B) Representative gross anatomical images of OVE4 and OVE4-Trp53ko mouse groups with opened peritoneal cavity. In OVE4 images, injected ovaries are indicated by yellow arrow. In OVE4-Trp53ko images, injected ovary and omentum are indicated by yellow arrow. (C) Summary of disease burden for OVE4 and OVE4-Trp53ko mouse groups. (D) Representative images of H&E-stained injected ovary sections from OVE4 and OVE4-Trp53ko mouse groups. Insets represent high magnification images of regions containing OVE cells. (E) IHC for Pax8 in serial ovary sections from OVE4 and OVE4-Trp53ko mouse groups. (F) Representative images of H&E-stained omentum sections from OVE4 and OVE4-Trp53ko mouse groups. Insets represent high magnification images of normal omentum for OVE4 images, and high magnification images of regions containing OVE cells for OVE4-Trp53ko image.
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