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This study illustrates the construction of Syrian hamster intrahepatic cholangiocyte organoids (shICOs), recapitulating the cold-resistance features of hibernators. shICOs demonstrate enhanced anti-ferroptosis ability under cold stress compared to mouse-derived organoids, providing a promising strategy to improve biliary cold preservation during liver transplantation.

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Chuman Wu, Changliang Wang, Meifeng Gu, Weiya He, Wenjun Deng, Wenjie Huang, Jiayu Liao, Changhui Li, Weilue Chen, Ruiping Chen, Ji Dong, Meiling Liu

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