Figure | Working principle of HyFMRI and in vivo experimental results. (IMAGE)
Caption
Figure | Working principle of HyFMRI and in vivo experimental results. a, schematic drawing of the hybrid multiplexed fluorescence and magnetic resonance imaging (HyFMRI) platform for measuring neuronal and astrocytic activity registered to concurrently recorded brain-wide hemodynamic responses. The platform incorporates a fiberscope-based optical (multichannel FL and optical intrinsic signal) imaging system and a custom surface radiofrequency (RF) coil into the bore of a preclinical MRI scanner. Custom 3D-printed components were designed to bridge the two modalities and provide animal support during the experiment. b-d, astrocytic, neuronal and hemodynamic brain activation patterns, respectively, evoked by external electrical forepaw stimulation from a representative mouse.
Credit
Zhenyue Chen et al.
Usage Restrictions
Credit must be given to the creator.
License
CC BY