Phospholipid hydrolysis regulates the function of innate immune cells (IMAGE)
Caption
Phospholipases PLA1, PLA2, PLC, and PLD hydrolyze phospholipids to produce corresponding lysophospholipids and fatty acids. Red arrows indicate the corresponding hydrolysis sites. B) Phospholipases PLA2, PLC, and PLD are expressed in various innate immune cells and play diversified role in shaping the function and activity of each cell type. This figure summarizes the functions of different subtypes of phospholipase PLA2, PLC, and PLD in innate immune cells. Abbreviations: PLA1, phospholipase A1; PLA2, phospholipase A2; PLC, phospholipase C; PLD, phospholipase D; LP-PLA2, lipoprotein-associated PLA2; ROS, reactive oxygen species; PLAG2D, PLA2 group IID; PAF-AH, platelet-activating factor acetyl hydrolase 2
Credit
Professor Juan Liu from Naval Medical University, Shanghai, China Image source link: https://link.springer.com/article/10.1007/s44466-025-00001-5
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