Vagus-dependent gut–brain signaling inMDMA-induced stress resilience. (IMAGE)

Genomic Press

Vagus-dependent gut–brain signaling inMDMA-induced stress resilience.

Caption

Vagus-dependent gut–brain signaling inMDMA-induced stress resilience. MDMA elevates central 5-HT and stimulates peripheral release of 5-HT from enterochromaffin cells, alongside oxytocin from enteroendocrine cells and the posterior pituitary. These gut-derived signals—together with bile acid changes—
activate vagal afferents in the intestinal wall, relaying to brainstem nuclei. Downstream modulation of limbic and cortical circuits enhances neuroplasticity, stress resilience, and adaptive behaviors.

Credit

Kenji Hashimoto

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License

CC BY

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