Innovations in Organoid Engineering (IMAGE)
Caption
As an emerging 3D cell culture system, organoid technology has demonstrated substantial potential in basic research and translational medicine by recapitulating in vivo organ structures and functions. Generated through methods like ALI culture, bioreactor systems, and vascularization strategies, organoids create representative models of kidneys, livers, lungs, and brains for multi-dimensional simulations of organ development, disease pathogenesis, and drug responses. By mimicking the in vivo microenvironment, this technology plays a pivotal role in biomedical research, facilitating HTS, establishing physiologically relevant toxicity assessment models, and advancing disease modeling and biobanking for precision medicine.
This review also explores emerging organoid technologies, such as 3D bioprinting for scalable model fabrication, microfluidic systems for dynamic microenvironment control, and genetically engineered organoids for gene-disease association studies. These innovations address traditional limitations in model consistency and complexity, opening new frontiers for mechanistic research and clinical applications, as well as offering novel technical support for accelerating the modernization and translational application of TCM.
Credit
Hongtao Jin
Usage Restrictions
Credit must be given to the creator. Only noncommercial uses of the work are permitted.
License
CC BY-NC