Ganoderma lucidum Alleviates High-fat Diet-induced Hepatic Lipotoxicity via Modulating the Unfolded Protein Response and Endoplasmic Reticulum-phagy (IMAGE)

Xia & He Publishing Inc.

Ganoderma lucidum Alleviates High-fat Diet-induced Hepatic Lipotoxicity via Modulating the Unfolded Protein Response and Endoplasmic Reticulum-phagy

Caption

High-fat diet-induced hepatic lipotoxicity elicits an inflammatory response along with adaptive UPR and ER-phagy, which may represent important therapeutic targets against lipotoxicity. In addition, G. lucidum shows protective effects against HFD-induced lipotoxicity, but its stimulatory effect on appetite should be carefully considered.

Credit

Mingzhu Yan, Qi Chang

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License

CC BY-NC

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