Proposed Mechanism of Action of DHA in Vas Deferens Smooth Muscle (IMAGE)
Caption
Noradrenaline (NA) activates α1A-adrenoceptors (α1A-AR), driving Ca2+ entry through two pathways that promote contraction: L-type voltage-dependent Ca2+ channels (L-type VDCC) and TRPC3/6 channels. Acute application of docosahexaenoic acid (DHA) preferentially suppresses the TRPC3/6-mediated component (blue block), thereby reducing the residual “fast/phasic” portion of the NA-evoked contraction even when L-type channels are blocked. The net effect is diminished Ca2+ influx and attenuation of rat vas deferens smooth muscle contraction.
Credit
Keisuke Obara
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