Syncing dosage time with a circadian clock can lead to a more sustained effect of dopamine reuptake inhibitors (IMAGE)

University of Michigan

Syncing dosage time with a circadian clock can lead to a more sustained effect of dopamine reuptake inhibitors

Caption

University of Michigan researchers have developed a model that shows how the dosage and timing of medicines that influence dopamine levels interact with circadian rhythms to have dramatic effects. These graphs show extracellular dopamine levels, or eda, as they vary naturally (gray) and in response to lower (blue) and higher (yellow) dosages of the drug modafinil. When taken early, during a "circadian trough," dopamine levels spike, but sustain more steadily compared to other scenarios that include spikes followed by crashes.

Credit

T. Yao and R. Kim, PLOS Comp. Biol. 2025, (DOI: 10.1371/journal.pcbi.1013508) Used under a CC BY license.

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