Multi-Mechanistic PtIrRuRhCu High-Entropy Alloy Nanozyme Mitigates Tendinopathy via ROS Scavenging, Mitophagy Restoration, and Ferroptosis Suppression through the PGAM5/FUNDC1/GPX4 Pathway (IMAGE)

Tsinghua University Press

Multi-Mechanistic PtIrRuRhCu High-Entropy Alloy Nanozyme Mitigates Tendinopathy via ROS Scavenging, Mitophagy Restoration, and Ferroptosis Suppression through the PGAM5/FUNDC1/GPX4 Pathway

Caption

This study developed a PtIrRuRhCu high-entropy alloy nanozyme (HEANZ) with excellent biocompatibility, which effectively alleviates tendinopathy pathological damage by scavenging ROS, restoring mitophagy, and inhibiting ferroptosis through upregulating the PGAM5/FUNDC1/GPX4 pathway.

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Nano Research, Nanjing University Press

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