Nanomaterial-Based STING Inhibition for Accelerated Bone Repair via Photothermal-Responsive Hydrogel Delivery (IMAGE)

Tsinghua University Press

Nanomaterial-Based STING Inhibition for Accelerated Bone Repair via Photothermal-Responsive Hydrogel Delivery

Caption

Schematic illustration of the GMHD/TFe@Aca hydrogel system: (1) Near-infrared (NIR) light triggers controlled release of acacetin from tannic acid-iron nanoparticles; (2) Acacetin inhibits STING pathway, reducing inflammation by suppressing M1 macrophages while promoting M2 polarization; (3) Enhanced bone regeneration occurs through collagen deposition, angiogenesis, and osteogenesis in cranial defects. The hydrogel demonstrates excellent mechanical strength and spatiotemporal drug release capabilities for precision bone repair.

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Shanghai University

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